ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
The frequency of hepatitis B virus reactivation in patients with bone marrow transplantation
1 Gaziantep Üniversitesi Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Gaziantep, Türkiye  
2 Gaziantep Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Gaziantep, Türkiye  
3 Gaziantep Üniversitesi Tıp Fakültesi, Hematoloji Anabilim Dalı, Gaziantep, Türkiye  
4 Gaziantep Üniversitesi Tıp Fakültesi, Kemik İliği Transplantasyonu Ünitesi, Gaziantep, Türkiye  
5 Gaziantep Üniversitesi Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Gaziantep, Türkiye  
6 Gaziantep Üniversitesi Tıp Fakültesi, Hematoloji Anabilim Dalı, Gaziantep, Türkiye; Gaziantep Üniversitesi Tıp Fakültesi, Kemik İliği Transplantasyonu Ünitesi, Gaziantep, Türkiye  
Gaziantep Med J 2017; 23: 67-73
DOI: 10.5152/EurJTher.2017.19
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Key Words: Bone marrow transplantation, hepatitis B reactivation, immunosuppressed host
Abstract

Objective: All patients with serologic evidence of a previous hepatitis B virus ( HBV )infection have the risk of reactivation. The present study aimed to determine the prevalence of HBV infection/reactivation and to identify possible factors causing reactivation in patients who underwent bone marrow transplantation.

 

Methods: In total, 442 patients who underwent allogeneic and autologous peripheral stem cell transplantation between April 2011 and December 2016 were included. Hepatitis B virus serologies, chemotherapy regimens received, and antiviral treatments were retrospectively evaluated.

 

Results: The number of HBsAg-positive patients was 36 (8.1%) and that of HBsAg-negative/anti-HBc-positive patients was 74 (16.7%); antiviral treatment was given to all patients. There was no HBV reactivation at the median follow-up of 21 months. 

 

Conclusion: All patients receiving immunosuppressive therapy should be screened for HBV infection and evaluated for the prophylactic treatment of HBV. Thus, the risk of HBV reactivation is minimized, and a preventive approach should always be considered for patients.

 

How to cite: Balkan A, Kırık MP, Gündeş İ, Haydaroğlu Şahin H, Budeyri S, Balkan Y, Gülşen MT, Pehlivan M. The frequency of hepatitis B virus reactivation in patients with bone marrow transplantation. Eur J Ther 2017; 23(2): 67-73.

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AVES | Copyright © 2017 European Journal of Therapeutics | Latest Update: 04.10.2017