ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Relationship between the frequency of hepatitis B virus infections and levels of serum adipokines in patients with hepatosteatosis and insulin resistance
1 Gaziantep Üniversitesi Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Gaziantep, Türkiye  
2 Gaziantep Üniversitesi Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Gaziantep, Türkiye  
3 Gaziantep Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Gaziantep, Türkiye  
Gaziantep Med J 2017; 23: 60-66
DOI: 10.5152/EurJTher.2017.20
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Key Words: Hepatosteatosis, insulin resistance, adipokine, hepatitis B virus

Objective: Although the steatogenic effect of hepatitis B virus (HBV) has been established in several studies, it is not yet known whether it leads to hepatosteatosis in anti-HBc IgG-positive patients. This study aimed to investigate the relationship between the frequency of HBV and levels of serum adipokines in patients with hepatosteatosis and insulin resistance.


Methods: Eighty patients diagnosed with hepatosteatosis by ultrasonography, who were admitted to our polyclinic between July 2011 and June 2012 for various reasons, and who had insulin resistance were included. Homeostasis model assessment-insulin resistance of >2.7 was considered as insulin resistance, and these patients was investigated for anti-HBc IgG. The anti-HBc IgG level was analyzed by enzyme-linked immunosorbent assay. Levels of adiponectin, resistin, and leptin in serum samples were analyzed in anti-HBc IgG (+) and anti-HBc IgG (−) groups.


Results: Anti-HBc IgG was positive in 29 (36.2%) patients and negative in 51 (63.8%). While the level of leptin in the anti-HBc IgG (+) group was 31569.72±14027.64 ng/mL, it was 25410.73±10978.26 ng/mL in the anti-HBc IgG (−) group. The levels of leptin in the anti-HBc IgG (+) and anti-HBc IgG (−) groups were statistically significant (p=0.047). However, levels of adiponectin and resistin were not different between the groups.



Conclusion: These results suggest that anti-HBc IgG positivity is involved in the etiology of hepatosteatosis and insulin resistance as well.

Key Words
AVES | Copyright © 2017 European Journal of Therapeutics | Latest Update: 13.07.2017