ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Comparison of Pulmonary Artery Catheter and Central Venous Catheter for Early Goal Directed Targeted Therapy in Sepsis and Septic shock
1 Department of Intensive Care, Dr. Ersin Arslan Research Hospital, Gaziantep, Turkey  
2 Department of Intensive Care, Melikgazi Hospital, Kayseri, Turkey  
3 Department of Internal Medicine and Intensive Care, Erciyes University School of Medicine, Kayseri, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2019.18020
Key Words: Sepsis, early goal directed therapy, septic shock

Objective: The aim of this study was to compare the effect of the pulmonary artery catheterization (PAC) method and the central venous catheterization (CVC) method on hemodynamic and inflammatory parameters in early goal-directed therapy (EGDT). 

This is a randomized prospective study. Patients with sepsis and septic shock within 12 hours of diagnosis were included in the study. Each group received strict protocolized resuscitation for 72 hours. 

Results: The mean age of the patients was 63.4 ± 14.5 years. The study included 15 males (52%) and 14 females (48%).  The length of stay in hospital and the duration of mechanical ventilation (MV) were similar between the two groups. The length of stay in the intensive care unit was shorter (P = 0.025) in the CVC group. High mobility group box- 1(HMGB-1) levels were lower at 72 hours in the CVC group (P = 0.026). In the early resuscitation period, it was found that in the CVC directed therapy group, the urine output and the mean arterial blood pressure were higher but vasoconstrictor need was lower (P < 0.05). 

Conclusion: In the early resuscitation period, CVC directed therapy is more effective and rapid correction of hemodynamic parameters results in shorter ICU stay. PAC is not superior to CVC guided therapy in the late period.

Key Words
AVES | Copyright © 2019 European Journal of Therapeutics | Latest Update: 11.03.2019