ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Apparent Diffusion Coefficient Values of Renal Parenchyma in Healthy Adults: A 3 Tesla MRI Study
1 Department of Radiology, Gaziantep University, School of Medicine, Gaziantep, Turkey  
Eur J Ther 2019; 25: 64-68
DOI: 10.5152/EurJTher.2019.18058
Key Words: Apparent diffusion coefficient, diffusion-weighted imaging, kidney


Objective: In this study, we aimed to measure apparent diffusion coefficient (ADC) values of healthy renal parenchyma using diffusion-weighted imaging (DWI) in a 3 Tesla (3T) magnetic resonance imaging (MRI) device.


Methods: Apparent diffusion coefficient values of right and left  renal parenchyma were measured in 87 individuals (64 females, 23 males) from DWIs obtained with a 3T MRI device. In the ADC measurement, bilateral renal parenchymal margins were drawn by the free-hand region of interest (ROI) on DWI (b=600 s/mm²), and ADCmean values were recorded from ROIs on the ADC map.


Results: The ADCmean value of renal parenchyma was 2.21x10−3 mm2/s and 2.2x10−3 mm2/s for the right and left kidney, respectively. Measured ADC values of the right and left renal parenchyma were highly consistent (Intraclass correlation coefficient (ICC=0.968; confidence interval (CI):[0.952–0.979]). ADC values of renal parenchyma were significantly lower in the group of patients older than or equal to 50 years as compared to the group of patients younger than 50 years (p=0.001). There was no significant difference between females and males in terms of the ADC values of renal parenchyma (p=0.161 for the right kidney, p=0.207 for the left kidney). Measured ADC values of the right and left renal parenchyma were highly consistent (ICC=0.968; CI:[0.952–0.979]). There was a strong negative correlation between ADC values of renal parenchyma and age (r=−0.686, p=0.001 for the right kidney; r=−0.759, p=0.001 for the left kidney).


Conclusion: Apparent diffusion coefficient values are quantitative values obtained by DWI, and it is important to understand the ADC values of normal healthy renal parenchyma in order to interpret ADC values in renal pathologies.

Key Words
AVES | Copyright © 2019 European Journal of Therapeutics | Latest Update: 11.03.2019