ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Can Ratio of Calcium with Albumin Predict the Severity of Aortic Stenosis?
1 Division of Cardiology, Necmettin Erbakan University School of Medicine, Konya, Turkey  
2 Division of Cardiology, Ahi Evran University, Training and Research Hospital, Kırşehir, Turkey  
3 Division of Cardiology, Atatürk Training and Research Hospital, Ankara, Turkey  
4 Division of Cardiology, Yildirim Beyazit University School of Medicine, Ankara, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2018.761
Key Words: Albumin, calcium, calcium/albumin ratio, aortic stenosis
Abstract

Objective: Aortic sclerosis is observed in 25% of the elderly population and 2.5% of these patients have severe aortic stenosis (AS). Numerous studies have reported a relationship between serum calcium or albumin levels and AS. The present study investigated the relationship between calcium/albumin ratio and AS.


Methods
: Our study included 185 patients and 108 subjects as control group. Routine transthoracic echocardiographic evaluation and laboratory examinations were performed to all participant. The corrected serum calcium levels were calculated using the most commonly used formula: Corrected calcium = measured total calcium (mg/dL) + 0.8 (4.0 − serum albumin [g/dL]).


Results
: Serum CRP, calcium and corrected calcium  levels  were significantly different between study groups (p < 0.05). And albumin levels were significantly decreased  in parallel to the severity of AS (p < 0.001). Also, we detected a negative correlation between albumin and corrected calcium levels and EuroSCORE. Calcium/albumin ratio and correctedcalcium/albumin ratio were significantly higher  in AS group as expected  (p < 0.01). In logistic regression analysis albumin, CRP, LDL, calcium/albumin ratio and correctedcalcium/albumin ratiolevels were found to be significantly and independently associated with the presence of AS (p < 0.05). Moreover, regression analysis in  subgroup of AS only albumin, correctedcalcium/albumin ratio and calcium/albumin ratio were independently associated with the presence of very severe AS.


Conclusion
: Our study showedan important relationship between calcium/albumin ratio and AS. Therefore, in clinical practice, this simple, inexpensive and practical method may be predicted the severity of AS.

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AVES | Copyright © 2018 European Journal of Therapeutics | Latest Update: 09.10.2018