ISSN 2564-7784 | E-ISSN 2564-7040
Review
Hypericum's 90th Year in A Laboratory
1 Department of Pathology Laboratory Techniques, Avrasya University Vocational School of Health Services, Trabzon, Turkey  
2 Department of Medical Pharmacology, Adnan Menderes University School of Medicine, Aydın, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2018.517
Key Words: Depression, hypericum perforatum, St John’s Wort, wound healing
Abstract

Hypericum Perforatum (HP) and its species are plants that have attracted the attention of science since 1931. In almost every country it is possible to encounter different species. While in many countries, it has been indicated as antidepressants, the commonly used types of HP in our country are mainly topical use in oil due to its wound healing properties. More than 50 constituents of its composition have been well established for many years and subject to detailed scientific studies such as antimicrobial, antineoplastic, antioxidant. The most noteworthy point of the extract in the daily practice is lack of standardization which may lead to inadequate treatment and adverse drug interactions. Although HPs’ anti-depressant and wound healing properties are accepted as traditional treatment agents, its side effects and safety profile limit its use in clinic; additionally, it seems exposures of  HP in pregnancy is an arising issue. Considering, a new molecule of candidate drug usually settle down to clinical use in 10-15 years, HP usage could not be safely establish in clinic as a drug for 90 years in spite of rigorous studies.

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