ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Surgical Treatment Results In Unilateral Wilms Tumor: Experience From A High-Volume Pediatric Oncology Center In Turkey
1 Division of Pediatric Surgery, Hacettepe University, School of Medicine, Ankara, Turkey  
2 Division of Pediatric Oncology, Hacettepe University, School of Medicine, Ankara, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2018.506
Key Words: Wilms tumor, survival, child, preoperative chemotherapy
Abstract

Objective: The aim of this study is to evaluate the clinical characteristics, factors effecting treatment approach and long-term outcome of patients with Wilms tumor.


Methods
: We identified demographic features, mode of presentation, applied treatments and long term outcomes of 88 patients treated between 1990-2011 at  Clinical Ethics Committee of Hacettepe University Faculty of Medicine.according to Turkish Pediatric Oncology Group protocol. Data were processed with SPSS programme and chi-square test was used for statistical analysis.


Results
: Study included 88 patients consisting of 50 females and 38 males and the mean age at presentation  was 3±2.48 years. Patients are classified as stage 1 (n=35, 39.8%), stage 2 (n=16, 18.2%), stage 3 (n=17, 19.3%) and stage 4 (n=20, 22.7%). Pathologic examination of tumors revealed favorable histology in 76 patients (86.4%) and unfavorable histology in 10 patients (11.4%). Forty nine patients (55.6%) received preoperative chemotherapy and patient’s age at diagnosis and the physical examination findings influence the decision of administration of preoperative chemotherapy (p<0.05). 25% of patients under 1 year of age and 75% of patients between 3-5 years old received preoperative chemotherapy. The palpated mass were crossing the midline in 20.5% of patients who were subjected to primary surgery. Tumor ruptured in 5.6% of patients intraoperatively. Long term prognosis of patients were as follows: 68 (83.9%) children were cured, 13 (16%) children died due to recurrences and metastasis. Survival rates reached 100% in stage 1 and 2 patients but decreased to 75% and 50% in stage 3 and 4 patients respectively.


Conclusion
: Age at presentation and physical examination findings are significant in surgical planning. Stage is the most important prognostic factor. Wilms tumor patients are treated with low complication and high survival rates due to multidisciplinary treatment approach at our institution.


How to cite
: User İR, Ekinci S, Karnak İ, Çiftçi AÖ, Büyükpamukçu M, Tanyel FC, et al. Surgical Treatment Results In Unilateral Wilms Tumor: Experience From A High-Volume Pediatric Oncology Center In Turkey. Eur J Ther 2018; DOI: 10.5152/EurJTher.2018.506

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AVES | Copyright © 2018 European Journal of Therapeutics | Latest Update: 09.10.2018