ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Effects of Voluntary and Forced Exercise on Anxiety-Related Behaviours and Motor Activity in Parkinson Mouse Model
1 Department of Physiology, Gaziantep University School of Medicine, Gaziantep, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2018.18011
Key Words: Parkinson's disease, voluntary exercise, forced exercise, anxiety, motor activity.
Abstract

Objective: This study was conducted to investigate the effect of two different types of exercise, voluntary and forced, on motor activity and anxiety in a neurotoxic parkinsonian mouse model.


Methods
: Parkinsonian mice with neurotoxin were performed voluntary and moderate forced exercise. Motor activity levels were then measured using rotarod and pole test. Therefore, anxiety was assessed by open field test and elevated plus maze test.


Results
: Bradykinesia, a motor dysfunction was assessed by the pole test. Tturn and Ttotal durations were significantly reduced in parkinson-induced forced exercise(p ˂0.001). Motor activity was assessed with the rotarod test and the best improvement was in the long-term forced exercise group (p˂0.001). The time spent on the opened arms in the elevated plus maze test or the spent time in the peripheral zone in the open field test is significantly shorter in the parkinson groups that performed forced exercise than the voluntary exercise groups. This suggests that the forced exercise group is more anxious.


Conclusion
: It had been shown that long-term forced exercise was the best exercise to improve motor function. Moderate intensity forced exercise has provided restorative effects on the motor symptoms of the disease. However, while this type of exercise increases anxiety, the voluntary exercise has a healing effect for anxiety. The data obtained in this study showed that exercise provided an effective improvement in motor skills and anxiety behaviors. So; exercise is an effective and non-invasive way to be safely recommended by clinicians to all parkinsonian patients.

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