ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
The effects of intravenously administered tramadol, dexketoprofen trometamol and midazolam in the management of renal colic pain; a prospective randomized study
1 Department of Emergency Medicine, Kilis Public Hospital, Kilis, Turkey  
2 Department of Emergency Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2017.334
Key Words: Renal colic, bedside ultrasonography, analgesic

Objective: To assess the effects of analgesic treatment combinations on ultrasonography findings and pain scales in people who were admitted to the emergency department of Gaziantep University Medical Faculty with renal colic pain.


Method: This was a prospective randomized clinical study, conducted in 100 people with renal colic pain who were admitted to the emergency department between September 2013 and September 2014. The patients were divided into four groups: the first group received tramadol, the second received dexketoprofen trometamol, the third received a tramadol-midazolam combination, and the fourth group received a dexketoprofen trometamol-midazolam combination. Blood pressure, pulse, and bedside renal ultrasonography (USG) findings were evaluated. Pain severity levels were assessed using the Visual Analog Scale (VAS) and the Renal Colic Symptom Score (RCSS), and were recorded as pre-treatment (0 minutes) and post-treatment (30 minutes) scores. These values were statistically compared.


Results: There was no statistically significant difference between the four groups in terms of gender and age (p=0.951 and p=0.890, respectively). A significant decrease was detected in the pre-treatment (0 minutes) and post-treatment (30 minutes) VAS and RCSS scores of all groups. The largest decrease occurred in the tramadol-midazolam group in the between-group comparison. In the evaluation of the alterations of the bedside USG findings, the largest change in renal parenchymal diameter of painful kidney also occurred in the tramadol-midazolam group.



Conclusion: The efficacy and safety of a tramadol-midazolam combination as an analgesic in renal colic may be used as an alternative, or add-on, therapy to currently available options.

Key Words
AVES | Copyright © 2018 European Journal of Therapeutics | Latest Update: 13.12.2018