ISSN 2564-7784 | E-ISSN 2564-7040
1 Department of Medical Biology and Genetics, İzmir Katip Çelebi University School of Medicine; Tissue Typing Laboratory, İzmir Katip Çelebi University School of Medicine, İzmir, Turkey  
Eur J Ther ; : -

Abstract

miRNAs are short, single stranded, noncoding RNA molecules with approximately 22 nucleotides. They play crucial roles in posttranscriptional regulation. To date, more than 21.000 mature miRNAs have been discovered from 193 species. miRNAs are important in kidney physiology, and their expressions may be specific to different organ tissues, or the same miRNAs may be expressed in different organs. With this discovery, it has been reported that tissue specific miRNAs can be used as biomarkers in allograft rejection and ischemia reperfusion injury after kidney transplantations. Although allograft biopsy is accepted as a gold standard, scientists have been developing novel approaches to prevent the risks such as bleeding and infection after biopsy. Recently, several attempts have been made in the use of urine as a non-invasive material in place of biopsy samples. However, there has been no procedure available for routine testing. Therefore, further investigations should be performed.

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