ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Effects of Pulsed Electromagnetic Fields on Lipid Peroxidation and Antioxidant Levels in Blood and Liver of Diabetic Rats
1 Gaziantep University, Vocational Higher School Of Health Services, Şehitkamil / Gaziantep, Turkey  
2 Gaziantep University, Department of Biophysics, Şehitkamil/Gaziantep, Turkey  
3 Gaziantep University, Department of Biochemistry, Şehitkamil/Gaziantep, Turkey  
Gaziantep Med J ; : -
DOI: 10.5152/EurJTher.2017.139
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Key Words: Antioxidants, diabetes, free radicals, oxidative stress, PEMF
Abstract

Objective: The present study investigated the protective effects of a pulsed electromagnetic field (PEMF) in a rat model of diabetes by analyzing oxidative/nitrosative stress parameters.

 

Methods: Rats were randomly divided into four groups of eight each: a control group, a sham PEMF group, a diabetes group, and a diabetes+PEMF group. Diabetes was induced in the sham PEMF, diabetes, and diabetes+PEMF groups by treatment with 50 mg/kg streptozotocin (STZ). Rats in the sham PEMF group were treated identically, without running the instrument. Following the development of diabetes, rats in the diabetes+PEMF group were treated with PEMF for 60 min/day for 4 weeks.

 

Results: Levels of oxidants, such as malondialdehyde (MDA), nitric oxide (NO), and myeloperoxidase (MPO), and antioxidants, such as superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT), were measured in blood and liver tissue samples. MPO, MDA, and NO levels were significantly higher, and SOD levels significantly lower, in the sham PEMF and diabetes groups than in the control group (p<0.05 each), whereas the levels of all these four (i.e., MPO, MDA, NO, and SOD) in the diabetes+PEMF group were close to those in the control group. GSH levels were significantly lower in the sham PEMF, diabetes, and diabetes+PEMF groups than in the control group (p<0.05 each), whereas CAT levels were similar in all the four groups.

 

Conclusion: Results indicate that PEMF affects MDA, NO, MPO, SOD, and GSH levels and regulates diabetes-associated damage by reducing oxidative stress and increasing the levels of antioxidants. PEMF may be a non-invasive treatment option for diabetes and associated complications.

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AVES | Copyright © 2017 European Journal of Therapeutics | Latest Update: 04.10.2017